A line-edge screw mixed dislocation beam possesses characteristics of both line-edge type and screw dislocation beams, resulting in more complex intensity and phase distributions during propagation, which makes a significant difference to enhancing the quality of biomedical imaging. Therefore，based on the generalized Huygens-Fresnel principle and the unified theory of coherence and polarization, the influence of several parameters on changes in both the spectral degree of coherence and the spectral degree of polarization has been numerically calculated and analyzed for partially coherent edge-screw mixed dislocation beams propagating in biological tissues, respectively. It is shown that both the spatial distribution and relative separation of field points have a distinct effect on the coherence and polarization properties. Compared with regular coherent vortices, the curves exhibit higher fluctuation frequency for irregular beams. As the off-axis distance of line-edge dislocation gradually increases, the propagation behaviors of the mixed dislocation beam tend to be simpler and simpler. Besides, the magnitude of spatial correlation lengths is more sensitive to spectral degree of polarization than to spectral degree of coherence.