In this paper, COMSOL Multiphysics finite element simulation software was used to numerically simulate the paint removal depth and temperature field distribution under different laser powers and scanning speeds, and the reliability of the simulation results was verified by experiments. The results show that the higher the laser power, the deeper the cleaning depth and the higher the surface temperature of the paint layer. The slower the scanning speed is, the deeper the cleaning depth is, and the flatter the cleaned surface is; when the scanning speed is too fast, the cleaning depth remains unchanged, and the flatness of the cleaned surface decreases. In addition, when the scanning speed is slow, the maximum temperature of the paint layer increases with the increase of the number of pulses until it stabilizes; when the scanning speed is too fast, the maximum temperature of the paint layer no longer changes with the increase of the number of pulses. The experimental results show that when the laser power is 20 W and the scanning speed is 1250 mm/s, there is no paint residue on the surface of the cleaned substrate, the surface quality is optimal, and it meets the requirements of the coating process.