This paper proposes a novel pixel-by-pixel depth error compensation method for Kinect2.0sensor.Firstly,a standard plane is obtained by Kinect2.0sensor in different positions.Secondly,according to the obtained three -dimensional (3D) data of the standard plan at different distances,the fitting plane which is the theoretical plane data is fitted by th e least squares method.Thirdly, calculate the depth error of Kinect2.0sensor pixel by pixel for establishing a 3D look-up table.Fourthly,through building up a 3D look-up table,depth value of each pixel is calculated by inte rpolation to realize the depth error compensation during measurement.The experimental results show that the proposed method can decrease the mean error of Kinect2.0to 0.8mm with the unknown internal parameters of Kinect 2.0.For the high precision application of Kinect2.0,this paper′s algorithm can achieve higher measure ment accuracy.