In view of the traditional laser Doppler′s low spatial resolution,based on diff erent distribution characteristics between static and dynamic scattering signals in spectrum,this paper proposes a full-field optical micro-angiography with low frame rate.The technique uses the sampling mode with low frame rate and short time exposure to capture scattering signal,and ensure enough pixels to obtain a full -field high spatial resolution image. The concentration image of blood erythrocytes phantom is realized through perfor ming Fourier transform to the time domain signal of particles and calculating the zero-moment of spectral power de nsity as the imaging parameters.In vivo experiments on GlassCatfish verify that this method is capable of providing a high-spatial-resolution microvessel map within 60μm.With a fundus camera,this technique is potential to develop a label-free full-field fundus optical angiography.