According to the mechanism of the optical thermal interaction between laser and biological tissue,the heat source generated in tissue under laser irradiation was investigated in a new viewpoint,and the correlativity of the optical thermal properties of laser irradiated tissue was also analyzed.A new heat transfer model for laser irradiated tissue has been developed based on the correlation,and several numerical simulation results in this paper were consistent with those in other published papers.This model can be treated as a promising tool in precisely predicting the thermal response induced by laser in clinic applicatinons.