黄正,龚玮,詹振林,李伟军,陈郁,谢树森.活体移植肾脏的OCT光学监测新技术[J].光电子激光,2016,27(7):782~786 |
活体移植肾脏的OCT光学监测新技术 |
Optical coherence tomography of living kidney in the transplantation |
投稿时间:2016-03-17 |
DOI: |
中文关键词: 肾脏移植 光学相干层析成像术 |
英文关键词:kidney transplant optical coherence tomography |
基金项目:“973”计划项目(2015CB352006)和福建省教育厅JK类项目(JK2015009)资助项目 (1.医学光电科学与技术教育部重点实验室,福建省光子技术重点实验,福建师范大学,福建福州,350007; 2.Fischell Department of Bioengineering,University of Maryland,Maryland,20742,USA) |
作者 | 单位 | 黄正 | 医学光电科学与技术教育部重点实验室,福建省光子技术重点实验,福建师范大学,福 建福州,350007 | 龚玮 | 医学光电科学与技术教育部重点实验室,福建省光子技术重点实验,福建师范大学,福 建福州,350007 | 詹振林 | 医学光电科学与技术教育部重点实验室,福建省光子技术重点实验,福建师范大学,福 建福州,350007 | 李伟军 | 医学光电科学与技术教育部重点实验室,福建省光子技术重点实验,福建师范大学,福 建福州,350007 | 陈郁 | Fischell Department of Bioengineering,University of Maryland,Maryland,20742,USA | 谢树森 | 医学光电科学与技术教育部重点实验室,福建省光子技术重点实验,福建师范大学,福 建福州,350007 |
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中文摘要: |
肾脏移植是救治终末期肾病(ESRD,end-stage re nal disease)患者的最佳方法。缺血造成的急 性肾小管坏死(ATN,acute tubular necrosis)是导致受体移植肾脏功能延迟恢复(DGF,d elayed graft function)和肾脏移植失败的主要因素。目前还没有一种能够准确地判定供 体肾脏是否发生ATN的无损方法。光学相干层析成像术(OCT)是一种新兴的医学成像技 术,可以对生物组织微小结构进行实时无损高分辨率成像。本文对肾脏移植过程中的光学相 干成像评估活体移植肾脏活性的新方法和技术做一综述。 |
英文摘要: |
The kidneys are vital organs that loca ted at the rear of the abdominal cavity in the retroperitioneal space.In case of non-reversible kidney failure (e.g.end-stage renal disease,ESRD),the patient have to require kidney transplant-a surgical procedure to replace diseased kidne y with a healthy donor kidney.However,acute tubular necrosis (ATN) induced by is chemia is a major risk factor for delayed graft function (DGF) and failure of kid ney transplant.Currently,there is no reliable non-invasive method for the detec tion of ATN in donor kidney.Optical coherence tomography (OCT) is an emerging me dical imaging technique that enables high-resolution cross-sectional imaging o f microstructures of biological tissues in situ and in real time.Animal and huma n studies suggest that OCT examination might provide a useful imaging tool in th e evaluation of the status of living kidney.As an optical biopsy tool,the advanc ed OCT system is able to visualize renal surface microstructure that could by us eful in monitoring donor kidney during kidney transplantation.In conjuction with laser Doppler,the OCT/DOCT imaging modality can reveal high-resolution 3D imag es of living kidney in real time.This review will provide an overview on the new method and technique in OCT examination of living kidney. |
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